DWARF 53 acts as a repressor of strigolactone
signalling in rice (Nature 504: 401-405, 2013)
IPA1 Functions as a Downstream Transcription Factor Repressed by D53 in Strigolactone Signaling in Rice
Xiaoguang Song, Zefu Lu, Hong Yu, Gaoneng Shao, Jinsong Xiong, Xiangbing Meng, Yanhui Jing, Guifu Liu, Guosheng Xiong, Jingbo Duan, Xue-Feng Yao, Chun-Ming Liu, Hongqing Li, Yonghong Wang and Jiayang Li

Cell Research

Strigolactones (SLs), a group of carotenoid derived terpenoid lactones, are root-to-shoot phytohormones suppressing shoot branching by inhibiting the outgrowth of axillary buds. DWARF 53 (D53), the key repressor of the SL signaling pathway, is speculated to regulate the downstream transcriptional network of SL response. However, no downstream transcription factor targeted by D53 has been reported so far yet. Here we report that Ideal Plant Architecture 1 (IPA1), a key regulator of the plant architecture in rice, functions as a direct downstream component of the D53 in regulating tiller number and SL-induced gene expression. We showed that D53 interacts with IPA1 in vivo and in vitro and suppresses the transcriptional activation activity of IPA1. We further showed that IPA1 could directly bind to the D53 promoter and play a critical role in the feedback regulation of SL-induced D53 expression. These findings reveal that IPA1 is likely one of the long-speculated transcription factors that act with D53 to mediate the SL-regulated tiller development in rice.

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